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Some chondrosarcomas have distinctive features under a microscope. These variants of chondrosarcoma can have a different prognosis (outlook) than usual chondrosarcomas.
Dedifferentiated chondrosacromas start out as typical chondrosarcomas but then some parts of the tumor change into cells like those of an osteosarcoma or fibrosarcoma. This variant of chondrosarcoma tends to occur in older patients and is more aggressive than usual chondrosarcomas.
Clear cell chondrosarcoma is a rare variant that grows slowly. It rarely spreads to other parts of the body unless it has already come back several times in the original location.
Mesenchymal chondrosarcomas can grow rapidly, but like Ewing tumor, are sensitive to treatment with radiation and chemotherapy.